Lisosa tsa psoriasis li kenyelletsa liphatsa tsa lefutso, 'mele oa ho itšireletsa mafung, tikoloho le lintlha tse ling,' me pathogenesis ea eona ha e e-s'o hlake ka ho feletseng.
1. Lintlha tsa lefutso
Liphuputso tse ngata li bontšitse hore lintlha tsa lefutso li phetha karolo ea bohlokoa ho pathogenesis ea psoriasis. Histori ea lelapa ea lefu lena e na le 10% ho 23.8% ea bakuli ba Chaena le ba ka bang 30% linaheng tse ling.Monyetla oa ho ba le ngoana ea nang le psoriasis ke 2% haeba ho se motsoali ea nang le lefu lena, 41% haeba batsoali ka bobeli ba e-na le lefu lena, le 14% haeba motsoali a le mong a e-na le lefu lena.Liphuputso tsa mafahla a amanang le psoriasis li bontšitse hore mafahla a monozygotic a na le monyetla oa 72% oa ho ba le lefu lena ka nako e le 'ngoe' me mafahla a dizygotic a na le monyetla oa 30% oa ho ba le lefu lena ka nako e le 'ngoe. Ho na le tse fetang 10 tseo ho thoeng ke susceptibility loci tse amanang haholo le nts'etsopele ea psoriasis.
2. Mabaka a ho itšireletsa mafung
Ts'ebetso e sa tloaelehang ea T-lymphocyte le ho kenella ka har'a epidermis kapa dermis ke likarolo tsa bohlokoa tsa pathophysiological ea psoriasis, e fanang ka maikutlo a ho kenya letsoho ha sesole sa 'mele ho nts'etsopele le tsoelo-pele ea lefu lena.Liphuputso tsa morao-rao li bontšitse hore tlhahiso ea IL-23 ka lisele tsa dendritic le lisele tse ling tsa antigen-presenting (APCs) li etsa hore ho be le phapang le ho ata ha CD4 + mothusi T lymphocyte, lisele tsa Th17 le lisele tse fapaneng tse hōlileng tsebong tsa Th17 li ka boloka mefuta e sa tšoaneng ea lisele tse kang Th17 tse kang e le IL-17, IL-21, le IL-22, e leng se susumetsang ho ata ho feteletseng ha lisele tse etsang keratin kapa karabelo ea ho ruruha ea lisele tsa synovial. Ka hona, lisele tsa Th17 le IL-23 / IL-17 axis li ka 'na tsa phetha karolo ea bohlokoa ho pathogenesis ea psoriasis.
3. Lintlha tsa Tikoloho le Metaboliki
Mabaka a tikoloho a phetha karolo ea bohlokoa ho hlohlelletsa kapa ho mpefatsa lefu la psoriasis, kapa ho lelefatsa lefu lena, ho kenyelletsa tšoaetso, khatello ea kelello, mekhoa e mebe (mohlala, ho tsuba, botahoa), ho sithabela maikutlo le ho itšoara ha meriana e itseng.Ho qala ha pitting psoriasis hangata ho amahanngoa le tšoaetso e matla ea streptococcal ea pharynx, 'me phekolo e khahlanong le tšoaetso e ka lebisa ntlafatsong le phokotsong kapa phokotsong ea maqeba a letlalo. Khatello ea kelello (e kang khatello ea kelello, mathata a ho robala, ho sebetsa ho feta tekano) ho ka etsa hore psoriasis e hlahe, e mpefatsa kapa e phete hape, 'me tšebeliso ea phekolo ea maikutlo a kelello e ka fokotsa boemo boo. Ho boetse ho fumanoa hore khatello ea mali, lefu la tsoekere, hyperlipidemia, lefu la methapo ea pelo le haholo-holo lefu la metabolic le na le sekhahla se phahameng har'a bakuli ba psoriasis.
Nako ea poso: Mar-17-2023
